What Is Apigenin? Apigenin is a bioflavonoid (flavone) compound that is found in a wide variety of fruits and vegetables. It is a naturally occurring substance that helps give plants their colors. In plants where it is very abundant, such as chamomile tea, it is known to help exert anxiety-reducing effects. Other plants that are known to have high levels of Apigenin in them are: grapefruits, onions, oranges and some spices such as parsley. Apigenin is also acts as a strong antioxidant and is considered a potent anti-cancer compound. It beneficially protects against a wide variety of cancers with high selectivity for cancer cells as opposed to non-cancerous cells. It also has a very high safety threshold, and active (anti-cancer) doses can be gained through consuming a vegetable and fruit rich diet. What Does Apigenin Do? Apigenin primarily works as an enzyme disruptor. By blocking or preventing certain enzymes from functioning around the body, it helps to provide various health benefits. Apigenin has been researched as a potentially potent anti-cancer compound. It primarily does this by disrupting or blocking enzymes that are known for creating tumors throughout the body. By blocking the enzymes and molecules that aid in the formation of cancer cells throughout the body, apigenin acts a preventative molecule, by limiting cancer causing agents in the first place. It has also shown in studies to act as a potent anti-inflammatory molecule. Supressing various enzymes that have shown to increase inflammation throughout the body. Hormonally speaking, Apigenin has been studied as a potent flavone that may help with the suppression of the aromatase enzyme in the body. Aromatase is the enzyme that is responsible for creating estrogen by breaking down testosterone. By blocking the aromatase enzyme from doing this, Apigenin can potentially help decease estrogen levels as well as increase testosterone levels over time. When interacting with adrenal cells, Apigenin has shown to help lower cortisol levels by up to 47.5%. What Are The Potential Benefits Of Apigenin? Anti-cancer agent Anti-inflammatory Aromatase inhibitor Reduce estrogen Increase testosterone Reduce Anxiety Reduce Cortisol/Stress How To Take Apigenin? For general health and wellbeing, most people can find sufficient amounts of Apigenin by consuming plants and vegetables. As a dietary supplement, typical daily dosages range from 100 mg – 500 mg per day. Side Effects Of Apigenin? As a completely natural substance found in many plants and vegetables, Apigenin is generally regarded as a very safe substance to supplement with. Although researchers have noted that at 100mg/kg Apigenin can become potentially toxic in rats. Meaning a 70 kg person would have to consume around 7,000 mg (7g) of the substance all at once to potentially be harmful.