What Is Bergamottin?
Bergamottin, (6’,7’-Dihydroxybergamottin) is a natural organic chemical compound found in grapefruit.
It is known as an inhibitor of the Cytochrome P450 enzyme (CYP450), an enzyme in the liver that is known to metabolize, (break down) various chemical compounds and drugs.
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What Does Bergamottin Do?
Bergamottin is widely known for it’s inhibitory effects of the CYP450 enzyme.
The CYP450 enzyme is found in the liver and the cells that line the intestines, where it plays an important role in the metabolism of drugs and other foreign substances/chemicals that are found in the body.
CYP450 targets these foreign substances and speeds up their removal from the body by oxidation.
After ingestion, bergamottin quickly gets to work by interacting with CYP450 and reducing its overall metabolic activity. This means that it slows down the rate at which CYP450 metabolizes and breaks down foreign substances.
These inhibitory effects make bergamottin a very useful substance to combine with other chemical compounds that would normally get broken down by CYP450.
For example, when the compound 1-DHEA is taken without bergamottin, CYP450 breaks it down so fast that the body will only get to use maybe 10% of the compound before it is broken down. However, when 1-DHEA is taken with bergamottin, the body is able to use 80%+ of the compound before it is broken down.
Bergamottin therefore has the potential to greatly enhance the bioavailability and efficacy of certain compounds when used appropriately.
What Are The Benefits Of Bergamottin?
- Inhibits CYP450 enzyme
- Boosts efficacy of certain compounds
How To Use Bergamottin?
Before choosing to use bergamottin to enhance the effectiveness of certain compounds, it is very important to do a lot of research beforehand.
There is a reason why many medications state, “do not drink grapefruit juice while taking this medicine”.
Dosages of bergamottin vary based on the compounds it is paired with. Effective dose ranges have been seen between 50 mg and 150 mg per day.
Side Effects Of Bergamottin?
Due to it’s inhibitory action of the CYP450 enzyme, it is very important to only use bergamottin when under controlled circumstances for specific compounds.
It is not advised to ever use bergamottin while taking prescription drugs.
Prescription drugs are created to give a specific amount of the compound factoring in proper function of the CYP450 enzyme. By limiting the effectiveness of CYP450 and taking prescription medication, serious side effects can occur.