What Exactly Is T2? T2 (3,5-diiodo-L-thyronine), also known as “Thyrotabs” or “TT’s” is a supplement that adds thyroid hormone to your body once ingested. T2 is the best legal non-prescription thyroid hormone, and is arguably better than T4 (thyroxine) or T3 (triiodothyronine). T2 is also one of the main ingredients in Red Supplement’s newest potent fat incinerator Red-Burner. Red Burner contains T2 as a main fat-loss ingredient. Enter The World of T2 (3,5-diiodo-L-thyronine) Anybody who isn’t still reading 1972 medical research on thyroid hormones should be aware that T2 is indeed very active in regards to its metabolic effects. It was once (decades ago) thought to be inactive, however, it is now proven to be VERY potent and it is a direct derivative of T3 itself. T2 in Clinical Studies on Animals: T3 and T2 were compared to one another mano-a-mano in a clinical study comparing their effect on resting metabolism and oxidative capacity of metabolically active tissues (effects on muscle tissue, fat, brown adipose tissue, liver, and heart). T2 had a blatant dose-dependent effect which increased resting metabolism and oxidative capacity, exponentially increasing how much fat you can lose. Another study showed very promising and similar results, increased energy expenditure and oxidative capacity as a result of T2. It soon became evident that T2 has a very similar effect on lipid metabolism that T3 itself has. 3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro In a study comparing the effects of T4, T3, and T2 on hepatic oxygen consumption specifically, they found that only T2 was able to stimulate rapid hepatic oxygen consumption. In short, it would theoretically work quicker to burn more energy (fat). Rapid stimulation of hepatic oxygen consumption by 3,5-di-iodo-l-thyronine T2 in Clinical Studies on Humans: In one study using human mononuclear blood cells, T2 increased the rate of respiration significantly. This was without inhibiting TSH (thyroid stimulating hormone) nearly as severely as T3 and T4 do. This means you can use T2 WITHOUT shutting down the natural production of your body’s own thyroid hormones. Biological effects of 3,5-diiodothyronine (T2) Another study also examined T2’s effect on TSH levels, and it took 13 times as much T2 to cause the same TSH inhibition that T3 did. Basically, it is much safer in respect to keeping your body in a state of homeostasis and ensuring natural and optimal organ function. 3,5-Diiodo-L-thyronine (T2) has selective thyromimetic effects in vivo and in vitro In a third more extreme human trial it appears as though it took 100 times more T2 than T3 to finally exert the same amount of TSH inhibition. Even using 400 times more T2 than T3, it appears that T3 only allows TSH to be inhibited to just a slight degree less than T2. The Thyroid Patient Advocacy-UK (TPA-UK) Response to: “A Statement from the British Thyroid Association Executive Committee on Armour® Thyroid” TSH (thyroid stimulating hormone) is a hormone your body releases when it needs to stimulate your body to produce more thyroid hormone. The higher this number is, the harder your thyroid is working to produce adequate thyroid levels. When you administer exogenous thyroid hormone to your body, it will signal your thyroid to stop producing thyroid hormones as it is already circulating in the blood stream from an external source. This causes your TSH to drop as there is no need for it to stimulate your body to produce thyroid hormones anymore. This is how thyroid suppression is caused via T3 and T4 use. Why T2 is better is that there is exponentially less TSH suppression than with other thyroid hormones. So you will be reaping the benefits of additional thyroid hormone circulating in your body, without shutting down your body’s natural production. T2 and Weight Loss The primary use for T2 supplementation is an enhanced level of metabolic function (fat loss). In a study addressing T2’s ability to burn fat it was seen that T2 decreased stored fat of rats fed with a high fat diet (*in a caloric surplus*) by 13% while the rats fed the same diet without T2 gained 13% mass, all fat. The control group had a normal diet (*maintenance calories*) and did not change in total body mass, fat or otherwise. 3, 5-diiodo-l-thyronine, by modulating mitochondrial functions, reverses hepatic fataccumulation in rats fed a high-fat diet Notable from this study, aside from the fact that T2 blatantly turbo charged fat loss in the rats that took it, it showed that T2 use for a month straight literally had ZERO negative effect on TSH (thyroid stimulating hormone), Thyroid Releasing Hormone (TRH), heart size, heart rate, or any other cause for concern. Most impressively, lean muscle mass was left completely intact in the T2 testing group, which is substantially different than studies performed on T3 (triiodothyronine) which have proven T3’s blatant propensity to eat up muscle mass. Essentially, T2 is a very beneficial supplement to increase your active circulating thyroid hormone, much like T3 and T4 hormones, without the side effects you would get from exogenous T3 or T4 use. Since using T3 can cause a state of hyperthyroidism which eats up muscle tissue will T2 do the same thing? It can yes, however, this is to a FAR less extreme extent. It would take ridiculously high doses for long durations of time to even come close to the same catabolic level (muscle wasting) that T3 has. To be on the safe side though, it is advisable you take measures to offset the possible slight chance of muscle catabolism. Two of the most basic and recommended measures I’d make are ensuring you are following a proper exercise routine, and eating an adequate amount of protein (at least 1 gram per pound body weight/ideally 1.5 grams per pound). Anabolic support (RED GROWTH) would prove especially useful alongside thyroid hormone use to 100% offset any muscle loss. While pretty much all steroids would get the job done, if you are opposed to sticking illegal drugs in your butt (which is a very understandable reason) but would still like the anabolic support necessary to guarantee the prevention of any potential muscle catabolism. We recommend implementing a prohormone into your supplementation. 1-DHEA via Red Growth would more than suffice to reduce your risk of muscle loss to near zero. T2 Can Change Your Muscle Fibers (In A Good Way) T2 increases muscle cellular insulin sensitivity by reducing the fat content in each cell. It accomplishes this by lowering the amount of circulating triglycerides in the body and eliminating the fat depositing process in red and white blood cells. Consequently, more amino acids in the body, carbohydrates and creatine are absorbed into each white muscle cell, allowing them to grow bigger than they would without T2 supplementation. Because T2 can increase white muscle cellular absorption, it can PERMANENTLY increase the maximum size and strength your body is capable of reaching. By altering the contents of your muscle fibers, T2 will promote less fat being stored in them, and increase the amount of energy (in carbohydrate form) that are stored in them, allowing you to get dryer, harder, and fuller looking muscle bellies saturated with extra glycogen. T2 vs T3 vs T4 You've probably heard of T3, triiodothyronine or cytomel, as well as T4, thyroxine, or Synthroid. T2 differs greatly as it is the only thryroid supplement that will not shut down your natural Thryoid production. Meaning, your body won’t stop producing its’ own thyroid hormones after taking T2, it will continue to operate as normal. T3 can be excessively catabolic, especially when used in a regimen that doesn’t include anabolic steroids to offset muscle loss. T2 on the other hand, can completely spare your hard earned muscle, but still burn tons of fat. The thyroid gland releases T4 and T3 into the bloodstream to regulate your metabolism. T4 is relatively inactive but is a precursor to active t3, which has been heavily popularized from competitive bodybuilders, and fat loss seekers. Scientific advances have resulted in a new thyroid hormone called “T2” which only has 2 iodide atoms. T3 has 3 iodide atoms, and T4 has 4. Through the removal process of these iodide atoms, the body enables their respective activity. Thyroid hormones ultimately serve as a regulator that decides the speed of which each cell in your body operates. By increasing your metabolism with T3 supplementation, you are extremely susceptible to imminent fat loss, as well as muscle loss. Obviously this is undesired as we want to keep all of our Gains. This is where T2 truly shines, as mentioned briefly earlier, it will make you lose fat via the same mechanisms T3 does, but it will help increase your muscle mass instead of eat away at it. Hypothyroidism, Hyperthyroidism, Cognitive Function The thyroid gland is responsible for the release of both T4 (thyroxine) and T3 (triiodothyronine), which ultimately determine your metabolic rate. If your body has a deficit of thyroid hormone, you can enter a state of hypothyroidism where your metabolism could drop as much as 40% below normal. In contrast, an excess of thyroid hormone can throw you into a state of hyperthyroidism where your metabolic rate could increase up to 60-100% above baseline. Thyroid hormones also play a huge role in your cognitive function, mood and blood profile. If they are out of whack or you are functioning with an inactive/underactive thyroid, you can run into a host of undesirable issues. Thyroid hormones exert their effects on the body via the metabolism of all macronutrients your body ingests. The greater the amount of thyroid hormones in your body, the higher your oxygen consumption will increase, as well as your Basal Metabolic Rate and lipolysis. It is obvious why those who are seeking a better physique would want to use thyroid hormones in their regimens. Lipids are oxidized at an exponentially increased rate the more thyroid hormone you have in your body, hence, you lose more body fat. The main issue in this lies in the fact that thyroid hormones (more specifically T3) are indifferent to what macronutrients they oxidize. Simply put, it will also increase your body’s protein oxidation. This puts you at a slightly increased risk of losing muscle mass. One notable lab study showed that in obese men that for every pound that each male lost via T3 administration, 1/3 of it was muscle mass, but 2/3 of it was pure fat loss. The effects of triiodothyronine on energy expenditure, nitrogen balance and rates of weight and fat loss in obese patients during prolonged caloric restriction. However, these were individuals who weren’t eating high protein diets or following strict bodybuilding resistance training regimens. Utilizing an optimal diet and training program would certainly make the disparity between muscle loss and fat loss much more favorable for the user. How can I increase my thyroid hormones naturally? Some notable natural supplements that “may” help increase your thyroid hormone include iodine or tyrosine. These may increase your thyroid hormone levels, however, the amount would be negligible, and there have been studies to show that iodine supplementation can actually impose negative effects while operating in a carb-restricted state (the most common style of cutting diet). T2 Summary T2 is relatively unknown in the fitness community and isn’t discussed a lot, simply due to the lack of knowledge of its existence. It can greatly benefit anyone’s training program and help you reach your physique goals. This powerful hormone, T2, is one of the main ingredients in our newest fat destroying supplement “Red-Burner”. Click here to order Red-Burner and see for yourself just how well T2 burns fat. Red Burner contains T2 as a main fat-loss ingredient.